EIF4ENIF1

Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesEIF4ENIF1, 4E-T, Clast4, eukaryotic translation initiation factor 4E nuclear import factor 1

External IDsOMIM: 607445; MGI: 1921453; HomoloGene: 10522; GeneCards: EIF4ENIF1; OMA:EIF4ENIF1 - orthologs

Chr.Chromosome 22 (human)^[1]

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EIF4ENIF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5ANR
Identifiers
Aliases	EIF4ENIF1, 4E-T, Clast4, eukaryotic translation initiation factor 4E nuclear import factor 1
External IDs	OMIM: 607445; MGI: 1921453; HomoloGene: 10522; GeneCards: EIF4ENIF1; OMA:EIF4ENIF1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 31,436,977 bp[1] End 31,496,108 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 2.24 cM Start 3,152,392 bp[2] End 3,194,588 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte left testis right testis sural nerve sperm cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum cerebellar vermis ventricular zone Top expressed in zygote genital tubercle tail of embryo secondary oocyte primary oocyte Rostral migratory stream interventricular septum thymus neural layer of retina epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding mRNA binding RNA binding nuclear export signal receptor activity Cellular component cytoplasm cytosol PML body nuclear speck P-body membrane intracellular membrane-bounded organelle nucleus Biological process protein transport stem cell population maintenance negative regulation of translation negative regulation of neuron differentiation transport nuclear export Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56478 74203 Ensembl ENSG00000184708 ENSMUSG00000020454 UniProt Q9NRA8 Q9EST3 RefSeq (mRNA) NM_001164501 NM_001164502 NM_019843 NM_001166547 NM_001166548 NM_001166549 NM_023743 RefSeq (protein) NP_001157973 NP_001157974 NP_062817 NP_001160019 NP_001160020 NP_001160021 NP_076232 Location (UCSC) Chr 22: 31.44 – 31.5 Mb Chr 11: 3.15 – 3.19 Mb PubMed search [3] [4]
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The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localization signal and nuclear export signals.^[6]