EIF4G3

EIF4G3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HU3
Identifiers
Aliases	EIF4G3, eIF-4G 3, eIF4G 3, eIF4GII, eukaryotic translation initiation factor 4 gamma 3
External IDs	OMIM: 603929; MGI: 1923935; HomoloGene: 2789; GeneCards: EIF4G3; OMA:EIF4G3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	21,177,285 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,208,508 bp
RNA expression pattern
	Top expressed in
	sperm; ; Epithelium of choroid plexus; ; right testis; ; left testis; ; frontal pole; ; Brodmann area 10; ; ventricular zone; ; epithelium of colon; ; lateral nuclear group of thalamus; ; middle frontal gyrus;
	Top expressed in
	muscle of thigh; ; tail of embryo; ; genital tubercle; ; neural layer of retina; ; seminiferous tubule; ; knee joint; ; cerebellar cortex; ; primary visual cortex; ; superior frontal gyrus; ; triceps brachii muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA cap binding; translation factor activity, RNA binding; translation initiation factor activity; RNA binding; protein binding; mRNA binding;
Cellular component	cytosol; eukaryotic translation initiation factor 4F complex;
Biological process	translational initiation; viral process; protein biosynthesis; regulation of translation; regulation of translational initiation; negative regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologs
	8672
	230861
	ENSG00000075151
	ENSMUSG00000028760
	O43432
	Q80XI3
NM_001198801; NM_001198802; NM_001198803; NM_003760; NM_001391892;
	NM_001391893; NM_001391894; NM_001391895; NM_001391896; NM_001391897; NM_001391898; NM_001391899; NM_001391900; NM_001391901; NM_001391902; NM_001391903; NM_001391904; NM_001391905; NM_001391906; NM_001391907
	NM_001256195; NM_001256198; NM_172703; NM_001355699; NM_001355700
	NP_001185730; NP_001185731; NP_001185732; NP_003751
NP_001243124; NP_001243127; NP_766291; NP_001342628; NP_001342629;
	NP_001356059; NP_001356060
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene.^[5]^[6] The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template.^[7] Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.^[8]