EMDT

EMDT
Clinical data
Other names	2-Ethyl-5-methoxy-N,N-dimethyltryptamine; 2-Ethyl-5-MeO-DMT; 2-Et-5-MeO-DMT
ATC code	none;
Identifiers
	IUPAC name 2-(2-ethyl-5-methoxy-1H-indol-3-yl)-N,N-dimethylethanamine;
CAS Number	263744-72-5 ;
PubChem CID	6918513;
IUPHAR/BPS	12;
ChemSpider	5293710 ;
UNII	GWM65988LJ;
ChEMBL	ChEMBL267615;
CompTox Dashboard (EPA)	DTXSID301336792 ;
Chemical and physical data
Formula	C15H22N2O
Molar mass	246.354 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCc2[nH]c1ccc(OC)cc1c2CCN(C)C;
	InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3 ; Key:ZEYRDXUWJDGTLD-UHFFFAOYSA-N ;
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2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT), also known as 2-ethyl-5-MeO-DMT, is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT₆ receptor agonist, with a K_i of 16 nM, and was one of the first selective agonists developed for this receptor.^[1]^[2] Its affinities for many other targets have also been reported.^[2] EMDT inhibits both short- and long-term memory formation in animal studies, and this effect can be reversed by the selective 5-HT₆ antagonist SB-399,885.^[3] Additionally, it is active in the tail suspension test, suggesting that it could be an effective antidepressant.^[4]