EPN2

Epsin-2 is a protein that in humans is encoded by the EPN2 gene.^[5][6]

AliasesEPN2, EHB21, epsin 2

External IDsOMIM: 607263; MGI: 1333766; HomoloGene: 40710; GeneCards: EPN2; OMA:EPN2 - orthologs

Chr.Chromosome 17 (human)^[1]

End19,336,715 bp^[1]

Quick facts Identifiers, Aliases ...

EPN2
Identifiers
Aliases	EPN2, EHB21, epsin 2
External IDs	OMIM: 607263; MGI: 1333766; HomoloGene: 40710; GeneCards: EPN2; OMA:EPN2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p11.2 Start 19,215,615 bp[1] End 19,336,715 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B2 Start 61,517,249 bp[2] End 61,579,687 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon corpus callosum amygdala C1 segment skin of abdomen skin of leg sural nerve ectocervix prefrontal cortex cingulate gyrus Top expressed in zygote secondary oocyte primary oocyte perirhinal cortex entorhinal cortex CA3 field dentate gyrus of hippocampal formation granule cell primary visual cortex spermatocyte superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lipid binding cadherin binding Cellular component cytoplasm intracellular membrane-bounded organelle cytoplasmic vesicle clathrin-coated vesicle clathrin coat of endocytic vesicle cytosol Biological process endocytosis membrane organization negative regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of Notch signaling pathway negative regulation of sprouting angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22905 13855 Ensembl ENSG00000072134 ENSMUSG00000001036 UniProt O95208 Q8CHU3 RefSeq (mRNA) NM_148921 NM_001102664 NM_014964 NM_001252188 NM_001252189 NM_010148 NM_001362585 NM_001362586 NM_001362587 RefSeq (protein) NP_001096134 NP_055779 NP_683723 NP_001239117 NP_001239118 NP_034278 NP_001349514 NP_001349515 NP_001349516 Location (UCSC) Chr 17: 19.22 – 19.34 Mb Chr 11: 61.52 – 61.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[6]