EPS8L2

Epidermal growth factor receptor kinase substrate 8-like protein 2 is an enzyme that in humans is encoded by the EPS8L2 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesEPS8L2, EPS8R2, EPS8 like 2, DFNB106

External IDsOMIM: 614988; MGI: 2138828; HomoloGene: 69358; GeneCards: EPS8L2; OMA:EPS8L2 - orthologs

Chr.Chromosome 11 (human)^[1]

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EPS8L2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WWU, 1WXB
Identifiers
Aliases	EPS8L2, EPS8R2, EPS8 like 2, DFNB106
External IDs	OMIM: 614988; MGI: 2138828; HomoloGene: 69358; GeneCards: EPS8L2; OMA:EPS8L2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 694,438 bp[1] End 727,727 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 140,918,793 bp[2] End 140,942,933 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left lobe of thyroid gland right lobe of thyroid gland minor salivary glands right lobe of liver right uterine tube mucosa of transverse colon skin of abdomen skin of leg amniotic fluid olfactory zone of nasal mucosa Top expressed in intestinal villus esophagus right kidney lip epithelium of small intestine duodenum yolk sac ileum jejunum pyloric antrum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding cadherin binding protein binding Cellular component ruffle membrane vesicle plasma membrane extracellular exosome cytoplasm cytosol stereocilium bundle stereocilium tip stereocilium protein-containing complex cell projection Biological process regulation of Rho protein signal transduction Rho protein signal transduction positive regulation of ruffle assembly hearing regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64787 98845 Ensembl ENSG00000177106 ENSMUSG00000025504 UniProt Q9H6S3 Q99K30 RefSeq (mRNA) NM_022772 NM_133191 RefSeq (protein) NP_073609 NP_573454 Location (UCSC) Chr 11: 0.69 – 0.73 Mb Chr 7: 140.92 – 140.94 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown.^[6]