Ephrin A3

Ephrin A3 is a protein that in humans is encoded by the EFNA3 gene.^[5][6]

AliasesEFNA3, EFL2, EPLG3, Ehk1-L, LERK3, ephrin A3

External IDsOMIM: 601381; MGI: 106644; HomoloGene: 3635; GeneCards: EFNA3; OMA:EFNA3 - orthologs

Chr.Chromosome 1 (human)^[1]

End155,087,538 bp^[1]

Quick facts EFNA3, Identifiers ...

EFNA3
Identifiers
Aliases	EFNA3, EFL2, EPLG3, Ehk1-L, LERK3, ephrin A3
External IDs	OMIM: 601381; MGI: 106644; HomoloGene: 3635; GeneCards: EFNA3; OMA:EFNA3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 155,078,837 bp[1] End 155,087,538 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.06 cM Start 89,313,899 bp[2] End 89,322,965 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen skin of arm hair follicle Region I of hippocampus proper cervix epithelium orbitofrontal cortex prefrontal cortex parotid gland nucleus accumbens Top expressed in lip perirhinal cortex entorhinal cortex chorion nasal epithelium olfactory epithelium subiculum skin of external ear dentate gyrus of hippocampal formation granule cell esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane-ephrin receptor activity protein binding ephrin receptor binding Cellular component anchored component of membrane plasma membrane integral component of plasma membrane membrane intrinsic component of plasma membrane Biological process cell-cell signaling ephrin receptor signaling pathway axon guidance negative regulation of angiogenesis regulation of neuron differentiation positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1944 13638 Ensembl ENSG00000143590 ENSMUSG00000028039 UniProt P52797 O08545 RefSeq (mRNA) NM_004952 NM_010108 RefSeq (protein) NP_004943 NP_034238 NP_001364045 NP_001364046 NP_001364047 NP_001364048 NP_001364049 NP_001364050 Location (UCSC) Chr 1: 155.08 – 155.09 Mb Chr 3: 89.31 – 89.32 Mb PubMed search [3] [4]
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This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin.^[6]