Exosome component 9

EXOSC9
Identifiers
Aliases	EXOSC9, PM/Scl-75, PMSCL1, RRP45, Rrp45p, p5, p6, Exosome component 9, PCH1D
External IDs	OMIM: 606180; MGI: 1355319; GeneCards: EXOSC9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NN6
Gene location (Human)
Chr.	Chromosome 4 (human)
End	121,817,021 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	36,619,876 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Achilles tendon; ; gonad; ; testicle; ; buccal mucosa cell; ; left testis; ; right testis; ; ventricular zone; ; ganglionic eminence; ; lymph node;
	Top expressed in
	otic vesicle; ; otic placode; ; saccule; ; Paneth cell; ; ventricular zone; ; trigeminal ganglion; ; spermatocyte; ; tail of embryo; ; endothelial cell of lymphatic vessel; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	3'-5'-exoribonuclease activity; exoribonuclease activity; protein binding; RNA binding; mRNA 3'-UTR AU-rich region binding;
Cellular component	cytoplasm; cytosol; exosome (RNase complex); nuclear exosome (RNase complex); nuclear chromosome; nucleolus; extracellular exosome; nucleus; nucleoplasm; cytoplasmic exosome (RNase complex);
Biological process	RNA processing; regulation of mRNA stability; nuclear polyadenylation-dependent rRNA catabolic process; nuclear-transcribed mRNA catabolic process; positive regulation of cell growth; nuclear mRNA surveillance; immune response; exonucleolytic catabolism of deadenylated mRNA; positive regulation of transcription by RNA polymerase II; rRNA processing; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; U1 snRNA 3'-end processing; U4 snRNA 3'-end processing; U5 snRNA 3'-end processing; nuclear polyadenylation-dependent tRNA catabolic process; nuclear polyadenylation-dependent mRNA catabolic process; rRNA catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5393
	50911
	ENSG00000123737
	ENSMUSG00000027714
	Q06265
	Q9JHI7
	NM_001034194; NM_005033
	NM_019393
	NP_001029366; NP_005024
	NP_062266
	Wikidata
View/Edit Human	View/Edit Mouse

Exosome component 9, also known as EXOSC9, is a human gene, the protein product of which (sometimes called RRP45 or PM/Scl-75) is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.^[5]