FAF1

FAS-associated factor 1 is a protein that in humans is encoded by the FAF1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesFAF1, HFAF1s, UBXD12, UBXN3A, hCGI-03, Fas associated factor 1

External IDsOMIM: 604460; MGI: 109419; HomoloGene: 5120; GeneCards: FAF1; OMA:FAF1 - orthologs

Chr.Chromosome 1 (human)^[1]

Quick facts Available structures, PDB ...

FAF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H8C, 2DZM, 2EC4, 3E21, 3QC8, 3QCA, 3QQ8, 3QWZ, 3QX1, 3R3M
Identifiers
Aliases	FAF1, HFAF1s, UBXD12, UBXN3A, hCGI-03, Fas associated factor 1
External IDs	OMIM: 604460; MGI: 109419; HomoloGene: 5120; GeneCards: FAF1; OMA:FAF1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.3 Start 50,437,028 bp[1] End 50,960,267 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C7|4 51.33 cM Start 109,533,785 bp[2] End 109,821,157 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle left testis right testis muscle of thigh ganglionic eminence glutes triceps brachii muscle ventricular zone Skeletal muscle tissue of rectus abdominis body of pancreas Top expressed in Paneth cell internal carotid artery facial motor nucleus external carotid artery digastric muscle spermatocyte triceps brachii muscle epithelium of lens temporal muscle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heat shock protein binding protein domain specific binding NF-kappaB binding ubiquitin binding protein binding protein kinase regulator activity protein kinase binding ubiquitin protein ligase binding Cellular component cytoplasm cytosol CD95 death-inducing signaling complex nuclear envelope VCP-NPL4-UFD1 AAA ATPase complex perinuclear region of cytoplasm nucleus Biological process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of cell death positive regulation of protein-containing complex assembly cytoplasmic sequestering of NF-kappaB regulation of cell adhesion regulation of protein catabolic process positive regulation of apoptotic process apoptotic process regulation of protein kinase activity proteasome-mediated ubiquitin-dependent protein catabolic process cell death positive regulation of DNA replication Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11124 14084 Ensembl ENSG00000185104 ENSMUSG00000010517 UniProt Q9UNN5 P54731 RefSeq (mRNA) NM_131917 NM_007051 NM_007983 RefSeq (protein) NP_008982 NP_032009 Location (UCSC) Chr 1: 50.44 – 50.96 Mb Chr 4: 109.53 – 109.82 Mb PubMed search [3] [4]
Wikidata
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Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.^[6]