FARSB

Phenylalanyl-tRNA synthetase beta chain is an enzyme that in humans is encoded by the FARSB gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesFARSB, FARSLB, FRSB, PheHB, PheRS, HSPC173, phenylalanyl-tRNA synthetase beta subunit, phenylalanyl-tRNA synthetase subunit beta, NEDBLLA, RILDBC, RILDBC1

External IDsOMIM: 609690; MGI: 1346035; HomoloGene: 4160; GeneCards: FARSB; OMA:FARSB - orthologs

Chr.Chromosome 2 (human)^[1]

Quick facts Available structures, PDB ...

FARSB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L4G
Identifiers
Aliases	FARSB, FARSLB, FRSB, PheHB, PheRS, HSPC173, phenylalanyl-tRNA synthetase beta subunit, phenylalanyl-tRNA synthetase subunit beta, NEDBLLA, RILDBC, RILDBC1
External IDs	OMIM: 609690; MGI: 1346035; HomoloGene: 4160; GeneCards: FARSB; OMA:FARSB - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q36.1 Start 222,566,899 bp[1] End 222,656,092 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C4 Start 78,394,612 bp[2] End 78,465,534 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle cardiac muscle tissue of right atrium gingival epithelium pancreatic epithelial cell pancreatic ductal cell skin of arm middle temporal gyrus Brodmann area 23 sperm epithelium of nasopharynx Top expressed in primitive streak tail of embryo genital tubercle Paneth cell condyle fossa secondary oocyte barrel cortex external carotid artery zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ligase activity nucleotide binding aminoacyl-tRNA ligase activity magnesium ion binding ATP binding RNA binding phenylalanine-tRNA ligase activity protein binding Cellular component membrane cytosol cytoplasm phenylalanine-tRNA ligase complex Biological process tRNA aminoacylation for protein translation protein biosynthesis protein heterotetramerization phenylalanyl-tRNA aminoacylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10056 23874 Ensembl ENSG00000116120 ENSMUSG00000026245 UniProt Q9NSD9 Q9WUA2 RefSeq (mRNA) NM_005687 NM_001278075 NM_011811 RefSeq (protein) NP_005678 NP_001265004 NP_035941 Location (UCSC) Chr 2: 222.57 – 222.66 Mb Chr 1: 78.39 – 78.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified.^[6]