FBP1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Fructose-1,6-bisphosphatase 1 is a protein that in humans is encoded by the FBP1 gene.[5]
External IDsOMIM: 611570; MGI: 95492; HomoloGene: 55467; GeneCards: FBP1; OMA:FBP1 - orthologs
Function
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.[5]The human FBP1 gene was cloned in 1988 by Solomon and colleagues at Memorial Sloan Kettering Cancer Center, who reported the cDNA sequence and expression pattern of the enzyme fructose‑1,6‑bisphosphatase in human tissues.[6]
