FBXO24

F-box only protein 24 is a protein that in humans is encoded by the FBXO24 gene.^[5][6][7]

AliasesFBXO24, FBX24, F-box protein 24

External IDsOMIM: 609097; MGI: 1918426; HomoloGene: 14131; GeneCards: FBXO24; OMA:FBXO24 - orthologs

Chr.Chromosome 7 (human)^[1]

End100,601,117 bp^[1]

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FBXO24
Identifiers
Aliases	FBXO24, FBX24, F-box protein 24
External IDs	OMIM: 609097; MGI: 1918426; HomoloGene: 14131; GeneCards: FBXO24; OMA:FBXO24 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 100,583,982 bp[1] End 100,601,117 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 137,610,765 bp[2] End 137,627,264 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm gonad testicle sural nerve granulocyte stromal cell of endometrium right uterine tube ectocervix Top expressed in spermatid seminiferous tubule granulocyte spermatocyte embryo embryo neural layer of retina esophagus jejunum ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding Cellular component ubiquitin ligase complex Biological process protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26261 71176 Ensembl ENSG00000106336 ENSMUSG00000089984 UniProt O75426 Q9D417 RefSeq (mRNA) NM_001163499 NM_012172 NM_033506 NM_027708 RefSeq (protein) NP_001156971 NP_036304 NP_277041 NP_081984 Location (UCSC) Chr 7: 100.58 – 100.6 Mb Chr 5: 137.61 – 137.63 Mb PubMed search [3] [4]
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates two transcript variants.^[7]