FBXO28

F-box only protein 28 is a protein that in humans is encoded by the FBXO28 gene.^[5][6]

AliasesFBXO28, CENP-30, Fbx28, F-box protein 28, DEE100

External IDsOMIM: 609100; MGI: 1261890; HomoloGene: 9050; GeneCards: FBXO28; OMA:FBXO28 - orthologs

Chr.Chromosome 1 (human)^[1]

End224,162,047 bp^[1]

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FBXO28
Identifiers
Aliases	FBXO28, CENP-30, Fbx28, F-box protein 28, DEE100
External IDs	OMIM: 609100; MGI: 1261890; HomoloGene: 9050; GeneCards: FBXO28; OMA:FBXO28 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.11 Start 224,114,111 bp[1] End 224,162,047 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H5|1 84.93 cM Start 182,140,667 bp[2] End 182,169,194 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle skin of thigh Epithelium of choroid plexus skin of hip endothelial cell kidney tubule Achilles tendon Brodmann area 23 tibia germinal epithelium Top expressed in zygote secondary oocyte primary oocyte external carotid artery internal carotid artery lacrimal gland submandibular gland motor neuron parotid gland retinal pigment epithelium More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 23219 67948 Ensembl ENSG00000143756 ENSMUSG00000047539 UniProt Q9NVF7 Q8BIG4 RefSeq (mRNA) NM_001136115 NM_015176 NM_175127 RefSeq (protein) NP_001129587 NP_055991 NP_780336 Location (UCSC) Chr 1: 224.11 – 224.16 Mb Chr 1: 182.14 – 182.17 Mb PubMed search [3] [4]
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Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM]^[6]