FBXO6

F-box only protein 6 is a protein that in humans is encoded by the FBXO6 gene.^[5][6][7]

AliasesFBXO6, FBG2, FBS2, FBX6, Fbx6b, F-box protein 6

External IDsOMIM: 605647; MGI: 1354743; HomoloGene: 9274; GeneCards: FBXO6; OMA:FBXO6 - orthologs

Chr.Chromosome 1 (human)^[1]

End11,674,354 bp^[1]

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FBXO6
Identifiers
Aliases	FBXO6, FBG2, FBS2, FBX6, Fbx6b, F-box protein 6
External IDs	OMIM: 605647; MGI: 1354743; HomoloGene: 9274; GeneCards: FBXO6; OMA:FBXO6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 11,664,200 bp[1] End 11,674,354 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 78.67 cM Start 148,230,173 bp[2] End 148,236,597 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte muscle of thigh gastrocnemius muscle bronchial epithelial cell blood right lobe of liver olfactory zone of nasal mucosa mucosa of ileum right adrenal gland Top expressed in urinary bladder muscle of thigh adrenal gland muscle tissue skeletal muscle tissue quadriceps femoris muscle placenta white adipose tissue lip right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin protein ligase activity carbohydrate binding ubiquitin-protein transferase activity protein binding Cellular component cytoplasm SCF ubiquitin ligase complex endoplasmic reticulum quality control compartment cytosol Biological process cellular response to DNA damage stimulus DNA damage checkpoint signaling SCF-dependent proteasomal ubiquitin-dependent protein catabolic process response to unfolded protein DNA repair protein ubiquitination proteolysis ubiquitin-dependent ERAD pathway glycoprotein catabolic process protein polyubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26270 50762 Ensembl ENSG00000116663 ENSMUSG00000055401 UniProt Q9NRD1 Q9QZN4 RefSeq (mRNA) NM_018438 NM_001163704 NM_001163705 NM_001163706 NM_001163707 NM_015797 RefSeq (protein) NP_060908 NP_001157176 NP_001157177 NP_001157178 NP_001157179 NP_056612 Location (UCSC) Chr 1: 11.66 – 11.67 Mb Chr 4: 148.23 – 148.24 Mb PubMed search [3] [4]
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.^[7]