FGD2

FGD2
Identifiers
Aliases	FGD2, ZFYVE4, FYVE, RhoGEF and PH domain containing 2
External IDs	OMIM: 605091; MGI: 1347084; HomoloGene: 8438; GeneCards: FGD2; OMA:FGD2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	37,029,069 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	29,379,661 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spleen; ; granulocyte; ; epithelium of nasopharynx; ; internal globus pallidus; ; lymph node; ; buccal mucosa cell; ; blood; ; trabecular bone; ; cardia;
	Top expressed in
	otic vesicle; ; saccule; ; spleen; ; granulocyte; ; blood; ; otic placode; ; islet of Langerhans; ; stroma of bone marrow; ; mesenteric lymph nodes; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol phosphate binding; metal ion binding; small GTPase binding; protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; endosome; Golgi apparatus; cell projection; early endosome membrane; membrane; ruffle; plasma membrane; ruffle membrane; early endosome; cytoskeleton; nucleus; lamellipodium;
Biological process	positive regulation of JUN kinase activity; regulation of GTPase activity; filopodium assembly; cytoskeleton organization; regulation of cell shape; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; actin cytoskeleton organization; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	221472
	26382
	ENSG00000146192
	ENSMUSG00000024013
	Q7Z6J4
	Q8BY35
	NM_173558
	NM_001159538; NM_013710
	NP_775829
	NP_001153010; NP_038738
	Wikidata
View/Edit Human	View/Edit Mouse

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.^[5]