FGF17

Fibroblast growth factor 17 is a protein that in humans is encoded by the FGF17 gene.^[5][6][7]

AliasesFGF17, FGF-13, HH20, FGF-17, fibroblast growth factor 17

External IDsOMIM: 603725; MGI: 1202401; HomoloGene: 2872; GeneCards: FGF17; OMA:FGF17 - orthologs

Chr.Chromosome 8 (human)^[1]

End22,048,809 bp^[1]

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FGF17
Identifiers
Aliases	FGF17, FGF-13, HH20, FGF-17, fibroblast growth factor 17
External IDs	OMIM: 603725; MGI: 1202401; HomoloGene: 2872; GeneCards: FGF17; OMA:FGF17 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 22,042,398 bp[1] End 22,048,809 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D2|14 36.4 cM Start 70,636,203 bp[2] End 70,642,268 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe testicle anterior cingulate cortex Brodmann area 9 gonad nucleus accumbens amygdala right lobe of thyroid gland caudate nucleus Top expressed in tail of embryo lumbar subsegment of spinal cord medial nasal prominence embryo embryo vasculature of trunk gray matter layer of cerebellum pulmonary artery descending aorta Descending thoracic aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibroblast growth factor receptor binding type 1 fibroblast growth factor receptor binding type 2 fibroblast growth factor receptor binding growth factor activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase activity Cellular component extracellular region intracellular anatomical structure extracellular space Biological process cell-cell signaling nervous system development MAPK cascade multicellular organism development fibroblast growth factor receptor signaling pathway positive regulation of cell population proliferation signal transduction phosphatidylinositol phosphate biosynthetic process peptidyl-tyrosine phosphorylation phosphatidylinositol-3-phosphate biosynthetic process regulation of signaling receptor activity positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8822 14171 Ensembl ENSG00000158815 ENSMUSG00000022101 UniProt O60258 P63075 RefSeq (mRNA) NM_001304478 NM_003867 NM_008004 NM_001360108 RefSeq (protein) NP_001291407 NP_003858 NP_032030 NP_001347037 Location (UCSC) Chr 8: 22.04 – 22.05 Mb Chr 14: 70.64 – 70.64 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes, including embryonic development cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene was shown to be prominently expressed in the cerebellum and cortex. The mouse homolog of this gene was localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, which suggests a role in central nervous system, bone and vascular development. This gene was referred to as FGF-13 in reference 2, however, its amino acid sequence and chromosomal localization are identical to FGF17.^[7]