FGF6

Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.^[5][6]

AliasesFGF6, HBGF-6, HST2, fibroblast growth factor 6

External IDsOMIM: 134921; MGI: 95520; HomoloGene: 10870; GeneCards: FGF6; OMA:FGF6 - orthologs

Chr.Chromosome 12 (human)^[1]

End4,445,815 bp^[1]

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FGF6
Identifiers
Aliases	FGF6, HBGF-6, HST2, fibroblast growth factor 6
External IDs	OMIM: 134921; MGI: 95520; HomoloGene: 10870; GeneCards: FGF6; OMA:FGF6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.32 Start 4,428,155 bp[1] End 4,445,815 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F3|6 61.92 cM Start 126,992,549 bp[2] End 127,005,150 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle skeletal muscle tissue oocyte external globus pallidus pars compacta secondary oocyte superior frontal gyrus duodenum urinary bladder Top expressed in triceps brachii muscle myotome ankle temporal muscle elbow tongue muscle soleus muscle tibialis anterior muscle sternocleidomastoid muscle embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibroblast growth factor receptor binding growth factor activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase activity Cellular component extracellular region sarcolemma intracellular anatomical structure extracellular space Biological process cell differentiation cell-cell signaling MAPK cascade multicellular organism development fibroblast growth factor receptor signaling pathway angiogenesis positive regulation of cell population proliferation cell population proliferation myoblast differentiation positive regulation of cell division cartilage condensation signal transduction phosphatidylinositol phosphate biosynthetic process peptidyl-tyrosine phosphorylation phosphatidylinositol-3-phosphate biosynthetic process regulation of signaling receptor activity positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2251 14177 Ensembl ENSG00000111241 ENSMUSG00000000183 UniProt P10767 P21658 RefSeq (mRNA) NM_020996 NM_010204 RefSeq (protein) NP_066276 NP_034334 Location (UCSC) Chr 12: 4.43 – 4.45 Mb Chr 6: 126.99 – 127.01 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation.^[6]