FNTA

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha is an enzyme that in humans is encoded by the FNTA gene.^[5][6]

AliasesFNTA, FPTA, PGGT1A, PTAR2, farnesyltransferase, CAAX box, alpha

External IDsOMIM: 134635; MGI: 104683; HomoloGene: 1534; GeneCards: FNTA; OMA:FNTA - orthologs

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 8 (human)^[1]

Quick facts Identifiers, Aliases ...

FNTA
Identifiers
Aliases	FNTA, FPTA, PGGT1A, PTAR2, farnesyltransferase, CAAX box, alpha
External IDs	OMIM: 134635; MGI: 104683; HomoloGene: 1534; GeneCards: FNTA; OMA:FNTA - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JCQ, 1LD7, 1LD8, 1MZC, 1S63, 1SA4, 1TN6, 2F0Y, 2H6F, 2H6G, 2H6H, 2H6I, 2IEJ, 3E37
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.5.1.58 ↗ ↗ ↗ ↗ 2.5.1.59 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.21 Start 43,034,194 bp[1] End 43,085,788 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A2|8 14.27 cM Start 26,488,750 bp[2] End 26,505,678 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium olfactory bulb subthalamic nucleus inferior ganglion of vagus nerve pancreatic ductal cell amniotic fluid parotid gland skin of hip germinal epithelium trigeminal ganglion Top expressed in medullary collecting duct facial motor nucleus fossa Paneth cell condyle vestibular membrane of cochlear duct renal corpuscle substantia nigra ciliary body ureter More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity protein prenyltransferase activity protein geranylgeranyltransferase activity microtubule binding Rab geranylgeranyltransferase activity receptor tyrosine kinase binding alpha-tubulin binding protein farnesyltransferase activity acetylcholine receptor regulator activity protein binding prenyltransferase activity CAAX-protein geranylgeranyltransferase activity Cellular component cytoplasm cytosol protein farnesyltransferase complex microtubule associated complex CAAX-protein geranylgeranyltransferase complex plasma membrane Biological process positive regulation of tubulin deacetylation protein prenylation protein geranylgeranylation neuromuscular junction development skeletal muscle acetylcholine-gated channel clustering positive regulation of deacetylase activity protein farnesylation transforming growth factor beta receptor signaling pathway neurotransmitter receptor metabolic process regulation of neurotransmitter receptor activity regulation of rhodopsin mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2339 14272 Ensembl ENSG00000168522 ENSMUSG00000015994 UniProt P49354 Q61239 RefSeq (mRNA) NM_001018676 NM_001018677 NM_002027 NM_008033 RefSeq (protein) NP_002018 NP_032059 Location (UCSC) Chr 8: 43.03 – 43.09 Mb Chr 8: 26.49 – 26.51 Mb PubMed search [3] [4]
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Prenyltransferases attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of protein's with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants encoding different isoforms.^[6]