FOLR2

Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesFOLR2, BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, folate receptor beta, FRbeta, FOLR1

External IDsOMIM: 136425; MGI: 95569; HomoloGene: 627; GeneCards: FOLR2; OMA:FOLR2 - orthologs

Chr.Chromosome 11 (human)^[1]

Quick facts Available structures, PDB ...

FOLR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KMY, 4KMZ, 4KN0, 4KN1, 4KN2
Identifiers
Aliases	FOLR2, BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, folate receptor beta, FRbeta, FOLR1
External IDs	OMIM: 136425; MGI: 95569; HomoloGene: 627; GeneCards: FOLR2; OMA:FOLR2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 72,216,601 bp[1] End 72,221,950 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 101,489,195 bp[2] End 101,506,401 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder right coronary artery synovial joint lymph node synovial membrane gonad pericardium decidua testicle rectum Top expressed in stroma of bone marrow lip ankle joint white adipose tissue esophagus muscle of thigh ankle mammary gland subcutaneous adipose tissue morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methotrexate binding folic acid binding folic acid receptor activity signaling receptor activity Cellular component cell surface anchored component of membrane anchored component of external side of plasma membrane membrane extracellular region plasma membrane Biological process inflammatory response receptor-mediated endocytosis positive regulation of cell population proliferation monocyte chemotaxis cellular response to folic acid folic acid metabolic process folic acid transport folate import across plasma membrane cell adhesion fusion of sperm to egg plasma membrane involved in single fertilization sperm-egg recognition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2350 14276 Ensembl ENSG00000165457 ENSMUSG00000032725 UniProt P14207 Q05685 RefSeq (mRNA) NM_000803 NM_001113534 NM_001113535 NM_001113536 NM_008035 NM_001303231 NM_001303239 RefSeq (protein) NP_000794 NP_001107006 NP_001107007 NP_001107008 NP_001290160 NP_001290168 NP_032061 Location (UCSC) Chr 11: 72.22 – 72.22 Mb Chr 7: 101.49 – 101.51 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence identity with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.^[7]