FOLR3
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Folate receptor gamma is a protein that in humans is encoded by the FOLR3 gene. It is involved in up-take of folic acid.[3]
| FOLR3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | FOLR3, FR-G, FR-gamma, gamma-hFR, folate receptor 3 (gamma), folate receptor 3, folate receptor gamma, FRgamma | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602469; HomoloGene: 88342; GeneCards: FOLR3; OMA:FOLR3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene location
The FOLR multi-gene family (FOLR1, FOLR2 and FOLR3) is localized to chromosome 11q13.3–q14.1, and encodes the gene products FRα, β and γ, respectively.[4]
Tissue distribution
FOLR3 is localized in haematopoietic tissue, such as spleen and bone marrow, and is present as a secretory protein. FOLR3 expresses in humans rather than mice and rats.[3]
Function
The FOLR3 gene is polymorphic due to a nonsense mutation resulting in a truncated protein; FRγ, which can bind folic acid. FOLR3 genes each consist of 5 exons, 4 introns and 1 promoter that encodes a single transcript.[3]
Clinical significance
Expression of FOLR3 is correlated more strongly with plasma homocysteine(Hcy) than FOLR1 and FOLR2. FOLR3 may decrease plasma Hcy compared with other FOLRs.[4] It was demonstrated that FOLR3 can metabolize both intracellular Hcy and extracellular Hcy. These results indicate that an increase in FOLR3 may effectively ameliorate Hcy in the blood and weaken Hcy-induced toxicity, even in tissues with the low level of FOLR1 and FOLR2 expression.[4]
