FOXN3

Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene.^[5][6]

AliasesFOXN3, C14orf116, CHES1, PRO1635, forkhead box N3

External IDsOMIM: 602628; MGI: 1918625; HomoloGene: 3809; GeneCards: FOXN3; OMA:FOXN3 - orthologs

Chr.Chromosome 14 (human)^[1]

End89,619,149 bp^[1]

Quick facts Identifiers, Aliases ...

FOXN3
Identifiers
Aliases	FOXN3, C14orf116, CHES1, PRO1635, forkhead box N3
External IDs	OMIM: 602628; MGI: 1918625; HomoloGene: 3809; GeneCards: FOXN3; OMA:FOXN3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q31.3-q32.11 Start 89,124,871 bp[1] End 89,619,149 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 99,156,337 bp[2] End 99,529,841 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in paraflocculus of cerebellum tendon of biceps brachii nipple saphenous vein skin of hip skin of arm mucosa of paranasal sinus skin of thigh synovial joint Skeletal muscle tissue of rectus abdominis Top expressed in zygote secondary oocyte hand ascending aorta soleus muscle Rostral migratory stream tibialis anterior muscle foot gastrocnemius muscle aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein C-terminus binding protein binding DNA-binding transcription factor activity sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process cell cycle mitotic G2 DNA damage checkpoint signaling negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated craniofacial suture morphogenesis cell differentiation positive regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1112 71375 Ensembl ENSG00000053254 ENSMUSG00000033713 UniProt O00409 Q499D0 RefSeq (mRNA) NM_005197 NM_001085471 NM_183186 RefSeq (protein) NP_001078940 NP_005188 NP_899009 Location (UCSC) Chr 14: 89.12 – 89.62 Mb Chr 12: 99.16 – 99.53 Mb PubMed search [3] [4]
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This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.^[6]