FRS3

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesFRS3, FRS2-beta, FRS2B, FRS2beta, SNT-2, SNT2, fibroblast growth factor receptor substrate 3

External IDsOMIM: 607744; MGI: 2135965; HomoloGene: 4845; GeneCards: FRS3; OMA:FRS3 - orthologs

Chr.Chromosome 6 (human)^[1]

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FRS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KUP, 2KUQ, 2YS5, 2YT2
Identifiers
Aliases	FRS3, FRS2-beta, FRS2B, FRS2beta, SNT-2, SNT2, fibroblast growth factor receptor substrate 3
External IDs	OMIM: 607744; MGI: 2135965; HomoloGene: 4845; GeneCards: FRS3; OMA:FRS3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 41,770,176 bp[1] End 41,786,542 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 47,999,955 bp[2] End 48,015,211 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum anterior cingulate cortex prefrontal cortex right frontal lobe Brodmann area 9 hypothalamus amygdala right testis apex of heart left testis Top expressed in neural layer of retina spermatocyte central gray substance of midbrain yolk sac primary visual cortex cerebellar cortex superior frontal gyrus nucleus of stria terminalis paraventricular nucleus of hypothalamus seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding fibroblast growth factor receptor binding identical protein binding Cellular component plasma membrane membrane intracellular anatomical structure Biological process fibroblast growth factor receptor signaling pathway signal transduction MAPK cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10817 107971 Ensembl ENSG00000137218 ENSMUSG00000023266 UniProt O43559 Q91WJ0 RefSeq (mRNA) NM_006653 NM_144939 RefSeq (protein) NP_006644 NP_659188 Location (UCSC) Chr 6: 41.77 – 41.79 Mb Chr 17: 48 – 48.02 Mb PubMed search [3] [4]
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The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.^[7]