Furethidine

Furethidine^[2][3][4] is a 4-phenylpiperidine derivative that is related to the clinically used opioid analgesic drug pethidine (meperidine),^[5] but with around 25x higher potency.^[6] According to another source, Furethidine is 500/30 = 16.7 x the potency of pethidine (table VII).^[7][8]

Other namesethyl 4-phenyl-1-(2-tetrahydrofurfuryloxyethyl)piperidine-4-carboxylate

ATC code

• none

Legal status

• AU: S9 (Prohibited substance)
• BR: Class A1 (Narcotic drugs)^[1]
• CA: Schedule I
• DE: Anlage I (Authorized scientific use only)
• UK: Class A
• US: Schedule I

CAS Number

• 2385-81-1

Quick facts Clinical data, Other names ...

Furethidine

Clinical data
Other names	ethyl 4-phenyl-1-(2-tetrahydrofurfuryloxyethyl)piperidine-4-carboxylate
ATC code	none
Legal status
Legal status	AU: S9 (Prohibited substance) BR: Class A1 (Narcotic drugs)[1] CA: Schedule I DE: Anlage I (Authorized scientific use only) UK: Class A US: Schedule I
Identifiers
IUPAC name ethyl 1-[2-(oxolan-2-ylmethoxy)ethyl]-4-phenylpiperidine-4-carboxylate
CAS Number	2385-81-1
PubChem CID	61306
DrugBank	DB01464 Y
ChemSpider	55245 Y
UNII	6U9XA4JOD4
KEGG	D12682 Y
ChEMBL	ChEMBL2105078
CompTox Dashboard (EPA)	DTXSID10862914
ECHA InfoCard	100.017.451
Chemical and physical data
Formula	C21H31NO4
Molar mass	361.482 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(OCC)C3(c1ccccc1)CCN(CCOCC2OCCC2)CC3
InChI InChI=1S/C21H31NO4/c1-2-25-20(23)21(18-7-4-3-5-8-18)10-12-22(13-11-21)14-16-24-17-19-9-6-15-26-19/h3-5,7-8,19H,2,6,9-17H2,1H3 Y Key:NNCOZXNZFLUYGG-UHFFFAOYSA-N Y
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Furethidine is not currently used in medicine and is a Class A/Schedule I drug which is controlled under UN drug conventions. It has similar effects to other opioid derivatives, such as analgesia, sedation, nausea and respiratory depression.^[9] In the United States it is a Schedule I Narcotic controlled substance with the ACSCN of 9626.^[10]