G6PC

Glucose-6-phosphatase, catalytic subunit (glucose 6-phosphatase alpha) is an enzyme that in humans is encoded by the G6PC gene.^[5][6]

AliasesG6PC1, glucose-6-phosphatase catalytic subunit, GSD1a, glucose-6-phosphatase catalytic subunit 1, GSD1, G6Pase, G6PC, G6PT

External IDsOMIM: 613742; MGI: 95607; HomoloGene: 20079; GeneCards: G6PC1; OMA:G6PC1 - orthologs

Chr.Chromosome 17 (human)^[1]

End42,914,438 bp^[1]

Quick facts G6PC1, Identifiers ...

G6PC1
Identifiers
Aliases	G6PC1, glucose-6-phosphatase catalytic subunit, GSD1a, glucose-6-phosphatase catalytic subunit 1, GSD1, G6Pase, G6PC, G6PT
External IDs	OMIM: 613742; MGI: 95607; HomoloGene: 20079; GeneCards: G6PC1; OMA:G6PC1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 42,900,797 bp[1] End 42,914,438 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 101,258,387 bp[2] End 101,268,729 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver kidney tubule buccal mucosa cell jejunal mucosa glomerulus metanephric glomerulus human kidney duodenum mucosa of ileum renal medulla Top expressed in right kidney human kidney left lobe of liver gallbladder proximal tubule jejunum epithelium of small intestine duodenum ileum Ileal epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphate ion binding phosphotransferase activity, alcohol group as acceptor hydrolase activity glucose-6-phosphatase activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle integral component of endoplasmic reticulum membrane endoplasmic reticulum Biological process phosphorylated carbohydrate dephosphorylation steroid metabolic process glucose homeostasis multicellular organism growth glycogen catabolic process urate metabolic process lipid homeostasis glycogen metabolic process regulation of gene expression response to food phosphate-containing compound metabolic process cholesterol homeostasis glucose 6-phosphate metabolic process triglyceride metabolic process glucose-6-phosphate transport gluconeogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2538 14377 Ensembl ENSG00000131482 ENSMUSG00000078650 UniProt P35575 P35576 RefSeq (mRNA) NM_001270397 NM_000151 NM_008061 RefSeq (protein) NP_000142 NP_001257326 NP_032087 Location (UCSC) Chr 17: 42.9 – 42.91 Mb Chr 11: 101.26 – 101.27 Mb PubMed search [3] [4]
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Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease).^[6]