GABPB2

GA-binding protein subunit beta-1 is a protein that in humans is encoded by the GABPB1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesGABPB1, BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, GABPB, GABPB2, NRF2B1, NRF2B2, GABPB-1, GA binding protein transcription factor beta subunit 1, GA binding protein transcription factor subunit beta 1

External IDsOMIM: 600610; MGI: 95611; HomoloGene: 7723; GeneCards: GABPB1; OMA:GABPB1 - orthologs

Chr.Chromosome 15 (human)^[1]

Quick facts GABPB1, Available structures ...

GABPB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AWC
Identifiers
Aliases	GABPB1, BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, GABPB, GABPB2, NRF2B1, NRF2B2, GABPB-1, GA binding protein transcription factor beta subunit 1, GA binding protein transcription factor subunit beta 1
External IDs	OMIM: 600610; MGI: 95611; HomoloGene: 7723; GeneCards: GABPB1; OMA:GABPB1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 50,275,389 bp[1] End 50,355,408 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 61.76 cM Start 126,469,362 bp[2] End 126,518,257 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte cartilage tissue bone marrow cell ventricular zone ganglionic eminence Achilles tendon stromal cell of endometrium testicle gonad lactiferous duct Top expressed in tail of embryo ventricular zone granulocyte genital tubercle thymus ganglionic eminence epiblast spermatid embryo primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity protein heterodimerization activity protein binding Cellular component nucleus nucleoplasm cytoplasmic ribonucleoprotein granule Biological process regulation of transcription, DNA-templated mitochondrion organization positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2553 14391 Ensembl ENSG00000104064 ENSMUSG00000027361 UniProt Q06547 Q00420 RefSeq (mRNA) NM_002041 NM_005254 NM_016654 NM_016655 NM_181427 NM_001320910 NM_001320915 NM_001271467 NM_001271468 NM_001271469 NM_001271470 NM_001271492 NM_010249 NM_207669 NM_001355108 NM_001355109 RefSeq (protein) NP_001307839 NP_001307844 NP_002032 NP_005245 NP_057738 NP_057739 NP_852092 NP_057738.1 NP_001258396 NP_001258397 NP_001258398 NP_001258399 NP_001258421 NP_034379 NP_997552 NP_001342037 NP_001342038 NP_001393121 NP_001393122 NP_001393123 NP_001393124 NP_001393125 NP_001393126 NP_001393127 NP_001393128 NP_001393129 NP_001393130 NP_001393131 NP_001393132 NP_001393133 NP_001393134 NP_001393135 NP_001393136 NP_001393137 NP_001393138 NP_001393139 NP_001393140 NP_001393141 NP_001393142 NP_001393143 NP_001393144 NP_001393145 NP_001393146 NP_001393147 NP_001393148 NP_001393149 NP_001393150 NP_001393151 NP_001393152 NP_001393153 NP_001393154 NP_001393155 NP_001393156 Location (UCSC) Chr 15: 50.28 – 50.36 Mb Chr 2: 126.47 – 126.52 Mb PubMed search [3] [4]
Wikidata
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This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene.^[6]