GABRQ

Gamma-aminobutyric acid receptor subunit theta is a protein that in humans is encoded by the GABRQ gene.^[5][6] The protein encoded by this gene is a subunit of the GABAA receptor.

AliasesGABRQ, THETA, gamma-aminobutyric acid type A receptor theta subunit, gamma-aminobutyric acid type A receptor subunit theta

External IDsOMIM: 300349; MGI: 1888498; HomoloGene: 10233; GeneCards: GABRQ; OMA:GABRQ - orthologs

Chr.X chromosome (human)^[1]

End152,657,542 bp^[1]

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GABRQ
Identifiers
Aliases	GABRQ, THETA, gamma-aminobutyric acid type A receptor theta subunit, gamma-aminobutyric acid type A receptor subunit theta
External IDs	OMIM: 300349; MGI: 1888498; HomoloGene: 10233; GeneCards: GABRQ; OMA:GABRQ - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 152,637,895 bp[1] End 152,657,542 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 71,868,784 bp[2] End 71,886,208 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hypothalamus gonad tibialis anterior muscle anterior cingulate cortex amygdala hippocampus proper superior vestibular nucleus ectocervix canal of the cervix prefrontal cortex Top expressed in secondary oocyte zygote ventromedial nucleus dorsomedial hypothalamic nucleus arcuate nucleus superior frontal gyrus lateral hypothalamus cerebellar cortex median eminence supraoptic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function GABA-A receptor activity neurotransmitter transmembrane transporter activity chloride channel activity extracellular ligand-gated ion channel activity ion channel activity transmembrane signaling receptor activity Cellular component integral component of membrane GABA-A receptor complex postsynaptic membrane membrane receptor complex plasma membrane synapse integral component of plasma membrane chloride channel complex cell junction neuron projection Biological process chloride transmembrane transport ion transport chloride transport signal transduction neurotransmitter transport ion transmembrane transport chemical synaptic transmission regulation of membrane potential nervous system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55879 57249 Ensembl ENSG00000268089 ENSMUSG00000031344 UniProt Q9UN88 Q9JLF1 RefSeq (mRNA) NM_018558 NM_001290435 NM_020488 RefSeq (protein) NP_061028 NP_001277364 NP_065234 Location (UCSC) Chr X: 152.64 – 152.66 Mb Chr X: 71.87 – 71.89 Mb PubMed search [3] [4]
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The θ subunit has highest sequence similarity with the β1 subunit.^[6] This subunit coassembles with:

• α2, β1, and γ1^[6]
• α3 and β1^[7]
• α3, β1, and ε.^[7]