GALNT3

Polypeptide N-acetylgalactosaminyltransferase 3 is an enzyme that in humans is encoded by the GALNT3 gene.^[5][6][7]

AliasesGALNT3, GalNAc-T3, HFTC, HHS, polypeptide N-acetylgalactosaminyltransferase 3, HFTC1

External IDsOMIM: 601756; MGI: 894695; HomoloGene: 55827; GeneCards: GALNT3; OMA:GALNT3 - orthologs

Chr.Chromosome 2 (human)^[1]

End165,794,659 bp^[1]

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GALNT3
Identifiers
Aliases	GALNT3, GalNAc-T3, HFTC, HHS, polypeptide N-acetylgalactosaminyltransferase 3, HFTC1
External IDs	OMIM: 601756; MGI: 894695; HomoloGene: 55827; GeneCards: GALNT3; OMA:GALNT3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q24.3 Start 165,747,588 bp[1] End 165,794,659 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.3 Start 65,913,110 bp[2] End 65,955,338 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon bronchial epithelial cell parotid gland jejunal mucosa rectum palpebral conjunctiva gingival epithelium pylorus right uterine tube duodenum Top expressed in parotid gland lacrimal gland submandibular gland spermatocyte spermatid right kidney seminiferous tubule conjunctival fornix epithelium of stomach mucous cell of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity calcium ion binding manganese ion binding glycosyltransferase activity metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein binding carbohydrate binding Cellular component integral component of membrane Golgi apparatus membrane Golgi membrane Golgi cisterna membrane perinuclear region of cytoplasm extracellular exosome Biological process protein O-linked glycosylation via serine protein glycosylation protein O-linked glycosylation via threonine O-glycan processing fibroblast growth factor receptor signaling pathway carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2591 14425 Ensembl ENSG00000115339 ENSMUSG00000026994 UniProt Q14435 P70419 RefSeq (mRNA) NM_004482 NM_015736 RefSeq (protein) NP_004473 NP_056551 Location (UCSC) Chr 2: 165.75 – 165.79 Mb Chr 2: 65.91 – 65.96 Mb PubMed search [3] [4]
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This gene encodes UDP-GalNAc transferase 3, a member of the polypeptide GalNAc transferase (GalNAc-T) family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members; however, the enzymes have different substrate specificities.^[7]