GAS5
Non-coding RNA in the species Homo sapiens
From Wikipedia, the free encyclopedia
Growth arrest-specific 5 is a non-protein coding RNA that in humans is encoded by the GAS5 gene.[3][4]
| GAS5 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | GAS5, NCRNA00030, SNHG2, growth arrest specific 5 (non-protein coding) | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 608280; GeneCards: GAS5; OMA:GAS5 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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GAS5 noncoding RNA, which accumulates in growth arrested cells, acts as a decoy hormone response element for the glucocorticoid receptor (GR) and hence blocks the upregulation of gene expression by activated GR.[5][6]
A number of studies have linked GAS5 to apoptosis and it may play a role in the progression of some types of cancer.[7][8][9]
The GAS5 introns host several snoRNA sequences, including SNORD81, SNORD47, SNORD80, SNORD79, SNORD78, SNORD44, SNORD77, SNORD76, SNORD75 and SNORD74.[4][10][11][12] These intronic sequences are more conserved than the exons of the host gene, these sorts of genes are often called "inside-out genes".[13]
It was recently discovered that the nonsense-mediated degradation pathway can regulate the function of the GAS5 in mammalian cells.[14]
