GBP1

GBP1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1DG3, 1F5N, 2B8W, 2B92, 2BC9, 2D4H
Identifiers
Aliases	GBP1, guanylate binding protein 1
External IDs	OMIM: 600411; HomoloGene: 133759; GeneCards: GBP1; OMA:GBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	89,065,360 bp
RNA expression pattern
	Top expressed in
	pericardium; ; trigeminal ganglion; ; mucosa of paranasal sinus; ; lower lobe of lung; ; superficial temporal artery; ; appendix; ; gallbladder; ; monocyte; ; tail of epididymis; ; epithelium of nasopharynx;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; Hsp90 protein binding; spectrin binding; protein binding; identical protein binding; enzyme binding; actin binding; hydrolase activity; cytokine binding; GTPase activity; GTP binding; GDP binding; protein homodimerization activity;
Cellular component	cytosol; membrane; Golgi membrane; plasma membrane; extracellular region; cytoplasm; Golgi apparatus; vesicle membrane; actin cytoskeleton; cytoplasmic vesicle;
Biological process	immune system process; interferon-gamma-mediated signaling pathway; negative regulation of T cell receptor signaling pathway; negative regulation of protein localization to plasma membrane; defense response to virus; regulation of calcium-mediated signaling; negative regulation of ERK1 and ERK2 cascade; negative regulation of substrate adhesion-dependent cell spreading; regulation of protein localization to plasma membrane; protein homooligomerization; cellular response to interferon-gamma; cellular response to interleukin-1; cellular response to tumor necrosis factor; protein localization to vacuole;
	Sources:Amigo / QuickGO
Orthologs
	2633
	n/a
	ENSG00000117228
	n/a
	P32455
	n/a
	NM_002053
	n/a
	NP_002044
	n/a
	Wikidata
View/Edit Human

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene.^[3]^[4] It belongs to the dynamin superfamily of large GTPases.^[5]