GCLC
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Glutamate–cysteine ligase catalytic subunit is an enzyme that in humans is encoded by the GCLC gene.[5][6]
Function
Glutamate–cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.[6]