GCS1

Mannosyl-oligosaccharide glucosidase is an enzyme that in humans is encoded by the MOGS gene.^[4][5][6]

AliasesMOGS, CDG2B, CWH41, DER7, GCS1, mannosyl-oligosaccharide glucosidase

External IDsOMIM: 601336; MGI: 1929872; HomoloGene: 4593; GeneCards: MOGS; OMA:MOGS - orthologs

Chr.Chromosome 6 (mouse)^[1]

End83,095,879 bp^[1]

Quick facts MOGS, Identifiers ...

MOGS
Identifiers
Aliases	MOGS, CDG2B, CWH41, DER7, GCS1, mannosyl-oligosaccharide glucosidase
External IDs	OMIM: 601336; MGI: 1929872; HomoloGene: 4593; GeneCards: MOGS; OMA:MOGS - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse)[1] Band 6|6 C3 Start 83,092,477 bp[1] End 83,095,879 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas body of stomach stromal cell of endometrium right uterine tube right lobe of thyroid gland minor salivary glands right lobe of liver left lobe of thyroid gland anterior pituitary upper lobe of left lung Top expressed in primitive streak Paneth cell condyle cumulus cell somite fossa fetal liver hematopoietic progenitor cell lacrimal gland epiblast abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glucosidase activity catalytic activity hydrolase activity hydrolase activity, acting on glycosyl bonds Glc3Man9GlcNAc2 oligosaccharide glucosidase activity Cellular component integral component of membrane extracellular exosome membrane endoplasmic reticulum endoplasmic reticulum membrane Biological process metabolism protein N-linked glycosylation protein folding oligosaccharide metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7841 57377 Ensembl n/a ENSMUSG00000030036 UniProt Q13724 Q80UM7 RefSeq (mRNA) NM_006302 NM_001146158 NM_020619 RefSeq (protein) NP_001139630 NP_006293 NP_065644 Location (UCSC) n/a Chr 6: 83.09 – 83.1 Mb PubMed search [2] [3]
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Glucosidase I is the first enzyme in the N-linked oligosaccharide processing pathway. GCS1 cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. GCS1 is located in the lumen of the endoplasmic reticulum.^[6]

GCS1 may also refer to "generative cell specific 1", also called HAP2 (hapless2), a gene of lower eukaryotes which is thought to be responsible for gametes fusion .^[7] .