GJA10

Gap junction alpha-10 protein, also known as connexin-62 (Cx62), is a protein that in humans is encoded by the GJA10 gene.^[5]

AliasesGJA10, CX62, gap junction protein alpha 10

External IDsOMIM: 611924; MGI: 1339969; HomoloGene: 7733; GeneCards: GJA10; OMA:GJA10 - orthologs

Chr.Chromosome 6 (human)^[1]

End89,921,760 bp^[1]

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GJA10
Identifiers
Aliases	GJA10, CX62, gap junction protein alpha 10
External IDs	OMIM: 611924; MGI: 1339969; HomoloGene: 7733; GeneCards: GJA10; OMA:GJA10 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 89,894,469 bp[1] End 89,921,760 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 14.25 cM Start 32,596,960 bp[2] End 32,602,760 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad left testis right testis prefrontal cortex Top expressed in embryo zygote neural layer of retina secondary oocyte primary oocyte subdivision of hippocampus Region I of hippocampus proper gland adipose tissue endocrine gland More reference expression data BioGPS n/a
Gene ontology Molecular function gap junction channel activity Cellular component integral component of membrane gap junction cell junction plasma membrane connexin complex membrane Biological process synapse assembly cell communication gamete generation transmembrane transport response to light stimulus detection of light stimulus involved in visual perception Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84694 14610 Ensembl ENSG00000135355 ENSG00000288435 ENSMUSG00000051056 UniProt Q969M2 Q9WUS4 RefSeq (mRNA) NM_032602 NM_010289 RefSeq (protein) NP_115991 NP_034419 Location (UCSC) Chr 6: 89.89 – 89.92 Mb Chr 4: 32.6 – 32.6 Mb PubMed search [3] [4]
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Connexins, such as GJA10, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.^[5][6]