GLRB

Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.^[5][6][7]

AliasesGLRB, HKPX2, glycine receptor beta

External IDsOMIM: 138492; MGI: 95751; HomoloGene: 20224; GeneCards: GLRB; OMA:GLRB - orthologs

Chr.Chromosome 4 (human)^[1]

End157,172,090 bp^[1]

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GLRB
Identifiers
Aliases	GLRB, HKPX2, glycine receptor beta
External IDs	OMIM: 138492; MGI: 95751; HomoloGene: 20224; GeneCards: GLRB; OMA:GLRB - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q32.1 Start 157,076,125 bp[1] End 157,172,090 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 E3|3 35.71 cM Start 80,750,906 bp[2] End 80,820,967 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole Brodmann area 10 middle frontal gyrus lateral nuclear group of thalamus pons paraflocculus of cerebellum Brodmann area 23 dorsolateral prefrontal cortex endothelial cell primary visual cortex Top expressed in lateral geniculate nucleus mammillary body pontine nuclei medial vestibular nucleus deep cerebellar nuclei lobe of cerebellum lateral hypothalamus dorsal tegmental nucleus cerebellar vermis lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycine binding protein binding extracellularly glycine-gated ion channel activity chloride channel activity extracellular ligand-gated ion channel activity extracellularly glycine-gated chloride channel activity ion channel activity transmembrane signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component cytoplasm integral component of membrane postsynaptic membrane cell projection membrane synapse chloride channel complex glycine-gated chloride channel complex cell junction dendrite integral component of plasma membrane plasma membrane GABA-ergic synapse glycinergic synapse neuron projection Biological process response to amino acid startle response protein heterooligomerization regulation of membrane potential gamma-aminobutyric acid receptor clustering chloride transmembrane transport nervous system development acrosome reaction neuromuscular process righting reflex chloride transport neuropeptide signaling pathway visual perception adult walking behavior ion transport synaptic transmission, glycinergic excitatory postsynaptic potential chemical synaptic transmission ion transmembrane transport signal transduction nervous system process regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2743 14658 Ensembl ENSG00000109738 ENSMUSG00000028020 UniProt P48167 P48168 RefSeq (mRNA) NM_000824 NM_001166060 NM_001166061 NM_001281969 NM_010298 NM_001345955 NM_001345956 NM_001345957 NM_001345958 NM_001345959 NM_001345996 RefSeq (protein) NP_000815 NP_001159532 NP_001159533 NP_001268898 NP_001332884 NP_001332885 NP_001332886 NP_001332887 NP_001332888 NP_001332925 NP_034428 Location (UCSC) Chr 4: 157.08 – 157.17 Mb Chr 3: 80.75 – 80.82 Mb PubMed search [3] [4]
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The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM]^[7]