GMEB1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Glucocorticoid modulatory element-binding protein 1 is a protein that in humans is encoded by the GMEB1 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesGMEB1, P96PIF, PIF96, glucocorticoid modulatory element binding protein 1
Quick facts Available structures, PDB ...
GMEB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGMEB1, P96PIF, PIF96, glucocorticoid modulatory element binding protein 1
External IDsOMIM: 604409; MGI: 2135604; HomoloGene: 10647; GeneCards: GMEB1; OMA:GMEB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006582
NM_024482
NM_001319674

NM_001122992
NM_020273

RefSeq (protein)

NP_001306603
NP_006573
NP_077808

NP_001116464
NP_064669

Location (UCSC)Chr 1: 28.67 – 28.72 MbChr 4: 132.22 – 132.26 Mb
PubMed search[3][4]
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Function

This gene is a member of KDWK gene family. The product of this gene associates with GMEB2 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist.[7]

Interactions

GMEB1 has been shown to interact with TRIM63.[8]

References

Further reading

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