GNG11

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 is a protein that in humans is encoded by the GNG11 gene.^[5][6]

AliasesGNG11, GNGT11, G protein subunit gamma 11, HG3H1

External IDsOMIM: 604390; MGI: 1913316; HomoloGene: 3045; GeneCards: GNG11; OMA:GNG11 - orthologs

Chr.Chromosome 7 (human)^[1]

End93,928,610 bp^[1]

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GNG11
Identifiers
Aliases	GNG11, GNGT11, G protein subunit gamma 11, HG3H1
External IDs	OMIM: 604390; MGI: 1913316; HomoloGene: 3045; GeneCards: GNG11; OMA:GNG11 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.3 Start 93,921,735 bp[1] End 93,928,610 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A1 Start 4,003,904 bp[2] End 4,008,445 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium tendon of biceps brachii periodontal fiber monocyte stromal cell of endometrium lactiferous duct germinal epithelium seminal vesicula parietal pleura placenta Top expressed in decidua blood right lung optic nerve right lung lobe left lung left lung lobe body of femur internal carotid artery external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity GTPase activity protein binding G-protein beta-subunit binding Cellular component plasma membrane membrane heterotrimeric G-protein complex G-protein beta/gamma-subunit complex Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2791 66066 Ensembl ENSG00000127920 ENSMUSG00000032766 UniProt P61952 P61953 RefSeq (mRNA) NM_004126 NM_025331 RefSeq (protein) NP_004117 NP_079607 Location (UCSC) Chr 7: 93.92 – 93.93 Mb Chr 6: 4 – 4.01 Mb PubMed search [3] [4]
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This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein.

As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas.^[6]