GOT1

Aspartate aminotransferase, cytoplasmic is an enzyme that in humans is encoded by the GOT1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesGOT1, ASTQTL1, GIG18, cAspAT, cCAT, AST1, glutamic-oxaloacetic transaminase 1

External IDsOMIM: 138180; MGI: 95791; HomoloGene: 1571; GeneCards: GOT1; OMA:GOT1 - orthologs

Chr.Chromosome 10 (human)^[1]

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GOT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3II0, 3WZF
Identifiers
Aliases	GOT1, ASTQTL1, GIG18, cAspAT, cCAT, AST1, glutamic-oxaloacetic transaminase 1
External IDs	OMIM: 138180; MGI: 95791; HomoloGene: 1571; GeneCards: GOT1; OMA:GOT1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.2 Start 99,396,870 bp[1] End 99,430,624 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 36.67 cM Start 43,488,191 bp[2] End 43,513,044 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle myocardium of left ventricle apex of heart cardiac muscle tissue of right atrium body of tongue right auricle of heart vastus lateralis muscle muscle of thigh Skeletal muscle tissue of rectus abdominis prefrontal cortex Top expressed in extraocular muscle right ventricle digastric muscle myocardium of ventricle medial vestibular nucleus temporal muscle sternocleidomastoid muscle pontine nuclei cardiac muscles deep cerebellar nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity L-aspartate:2-oxoglutarate aminotransferase activity L-cysteine:2-oxoglutarate aminotransferase activity transaminase activity catalytic activity carboxylic acid binding L-phenylalanine:2-oxoglutarate aminotransferase activity phosphatidylserine decarboxylase activity pyridoxal phosphate binding Cellular component cytoplasm axon terminus mitochondrion lysosome extracellular exosome nucleus nucleoplasm cytosol Biological process Notch signaling pathway gluconeogenesis dicarboxylic acid metabolic process aspartate metabolic process aspartate catabolic process cellular amino acid metabolic process response to glucocorticoid cellular amino acid biosynthetic process biosynthesis 2-oxoglutarate metabolic process oxaloacetate metabolic process glutamate catabolic process to 2-oxoglutarate aspartate biosynthetic process fatty acid homeostasis cellular response to insulin stimulus glutamate catabolic process to aspartate glutamate metabolic process glycerol biosynthetic process response to carbohydrate positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of collagen biosynthetic process response to immobilization stress response to cadmium ion negative regulation of cytosolic calcium ion concentration negative regulation of mitochondrial depolarization transdifferentiation cellular response to mechanical stimulus response to transition metal nanoparticle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2805 14718 Ensembl ENSG00000120053 ENSMUSG00000025190 UniProt P17174 P05201 RefSeq (mRNA) NM_002079 NM_010324 RefSeq (protein) NP_002070 NP_034454 Location (UCSC) Chr 10: 99.4 – 99.43 Mb Chr 19: 43.49 – 43.51 Mb PubMed search [3] [4]
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Glutamic–oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.^[6]