GPR116

ADGRF5
Identifiers
Aliases	ADGRF5, KPG_001, GPR116, adhesion G protein-coupled receptor F5
External IDs	MGI: 2182928; HomoloGene: 9065; GeneCards: ADGRF5; OMA:ADGRF5 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	46,954,943 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	43,770,448 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; visceral pleura; ; right lung; ; upper lobe of lung; ; upper lobe of left lung; ; renal medulla; ; right ventricle; ; metanephric glomerulus; ; vena cava; ; pericardium;
	Top expressed in
	right lung; ; right lung lobe; ; left lung lobe; ; endothelial cell of lymphatic vessel; ; interventricular septum; ; myocardium of ventricle; ; extraocular muscle; ; digastric muscle; ; soleus muscle; ; brown adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; apical part of cell; cytoplasmic vesicle; membrane;
Biological process	surfactant homeostasis; negative regulation of macrophage activation; G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; energy reserve metabolic process; regulation of lipid metabolic process; fat cell differentiation; positive regulation of phospholipid biosynthetic process; glucose homeostasis; signal transduction; glomerular filtration; erythrocyte development; pharyngeal arch artery morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	221395
	224792
	ENSG00000069122
	ENSMUSG00000056492
	Q8IZF2
	G5E8Q8
	NM_001098518; NM_015234
	NM_001081178; NM_001357332
	NP_001091988; NP_056049
NP_001074647; NP_001344261; NP_001391458; NP_001391459; NP_001391465;
	NP_001391470; NP_001391475; NP_001391477
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene.^[5]^[6]^[7] GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.^[8]^[9]