GPR123

ADGRA1
Identifiers
Aliases	ADGRA1, GPR123, adhesion G protein-coupled receptor A1
External IDs	OMIM: 612302; MGI: 1277167; HomoloGene: 18582; GeneCards: ADGRA1; OMA:ADGRA1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	133,131,675 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	139,458,004 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; hypothalamus; ; lateral nuclear group of thalamus; ; primary visual cortex; ; amygdala; ; ventricular zone;
	Top expressed in
	facial motor nucleus; ; lumbar subsegment of spinal cord; ; medial dorsal nucleus; ; Rostral migratory stream; ; substantia nigra; ; lateral geniculate nucleus; ; medial geniculate nucleus; ; subiculum; ; dentate gyrus of hippocampal formation granule cell; ; amygdala;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; membrane; postsynaptic density; glutamatergic synapse;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	84435
	52389
	ENSG00000197177
	ENSMUSG00000025475
	Q86SQ6
	Q8C4G9
	NM_001083909; NM_001291085; NM_032422
	NM_177469
	NP_001077378; NP_001278014
	NP_803420
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene.^[5]^[6] It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[7]^[8]^[9]