GPR128
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
G protein-coupled receptor 128 is a protein encoded by the ADGRG7 gene.[5][6][7] GPR128 is a member of the adhesion GPCR family.[8][9] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[10]
| ADGRG7 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | ADGRG7, GPR128, adhesion G protein-coupled receptor G7 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 612307; MGI: 2441732; HomoloGene: 13115; GeneCards: ADGRG7; OMA:ADGRG7 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Tissue distribution
GPR128 is specifically expressed in human liver as well as in mouse bone marrow and intestinal tissues.[11]
Function
Ni et al. showed that Gpr128 deletion in mice causes reduced body weight and induced intestinal contraction frequency.[12]
Clinical significance
A 111-kb copy number gain with breakpoints within the TRK-fused gene (a target of translocations in lymphoma and thyroid tumors) and GPR128 has been identified in the genome of patients with atypical myeloproliferative neoplasms.[13] Notably, the fused gene was also detected in few healthy individuals.