GPR133

ADGRD1
Identifiers
Aliases	ADGRD1, PGR25, GPR133, adhesion G protein-coupled receptor D1
External IDs	OMIM: 613639; MGI: 3041203; HomoloGene: 34616; GeneCards: ADGRD1; OMA:ADGRD1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	131,141,469 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	129,281,663 bp
RNA expression pattern
	Top expressed in
	cardiac muscle tissue of right atrium; ; right auricle of heart; ; tibial nerve; ; decidua; ; right lung; ; sural nerve; ; upper lobe of left lung; ; myocardium of left ventricle; ; gastric mucosa; ; apex of heart;
	Top expressed in
	lumbar spinal ganglion; ; Ileal epithelium; ; lactiferous gland; ; ankle joint; ; extraocular muscle; ; white adipose tissue; ; body of femur; ; sciatic nerve; ; ascending aorta; ; thoracic diaphragm;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane; intracellular anatomical structure; integral component of plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	283383
	243277
	ENSG00000111452
	ENSMUSG00000044017
	Q6QNK2
	Q80T32
	NM_198827; NM_001330497
	NM_001081342; NM_177734; NM_001347486
	NP_001317426; NP_942122
	NP_001074811; NP_001334415
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene.^[5]^[6]

AliasesADGRD1, PGR25, GPR133, adhesion G protein-coupled receptor D1

External IDsOMIM: 613639; MGI: 3041203; HomoloGene: 34616; GeneCards: ADGRD1; OMA:ADGRD1 - orthologs

Chr.Chromosome 12 (human)^[1]

End131,141,469 bp^[1]

Quick facts ADGRD1, Identifiers ...

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This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[7]^[8]

GPR133 binds androgens, specifically the androgen 5α-dihydrotestosterone (5α-DHT).^[9] GPR133 is an adhesion G protein-coupled receptor that functions as a membrane receptor for androgens. When activated by 5α-DHT, GPR133 increases intracellular cyclic AMP (cAMP) levels in muscle cells, leading to enhanced muscle strength.^[9]

Agonists of GPR133 such as GL64 and AP503 have potential applications in the treatment of osteoporosis.^[10]^[11]

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GPR133

References

Further reading

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