GPR143

Available protein structures:
PDB	IPR001414 PF02101 (ECOD; PDBsum)
AlphaFold	IPR001414; PF02101;

Ocular albinism type 1 protein
Ocular albinism type 1 protein
Identifiers
Symbol	Ocular_alb
Pfam	PF02101
Pfam clan	CL0192
InterPro	IPR001414
PDB
Available protein structures:
PDB	IPR001414 PF02101 (ECOD; PDBsum)
AlphaFold	IPR001414; PF02101;

GPR143
Identifiers
Aliases	GPR143, NYS6, OA1, G protein-coupled receptor 143
External IDs	OMIM: 300808; MGI: 107193; HomoloGene: 230; GeneCards: GPR143; OMA:GPR143 - orthologs
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	151,591,642 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; retinal pigment epithelium; ; caudate nucleus; ; nucleus accumbens; ; putamen; ; cingulate gyrus; ; amygdala; ; skin of abdomen; ; Brodmann area 9;
	Top expressed in
	iris; ; retinal pigment epithelium; ; hair follicle; ; ciliary body; ; embryo; ; stria vascularis; ; embryo; ; morula; ; endothelial cell of lymphatic vessel; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	L-DOPA binding; G protein-coupled receptor activity; signal transducer activity; dopamine binding; tyrosine binding; protein binding; L-DOPA receptor activity;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; membrane; melanosome; melanosome membrane; lysosomal membrane; apical plasma membrane; lysosome; plasma membrane;
Biological process	eye pigment biosynthetic process; regulation of melanosome transport; melanosome localization; melanosome organization; melanosome transport; regulation of calcium-mediated signaling; regulation of melanosome organization; calcium-mediated signaling using intracellular calcium source; phosphatidylinositol-mediated signaling; signal transduction; visual perception; neuropeptide signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4935
	18241
	n/a
	ENSMUSG00000025333
	P51810
	P70259
	NM_000273
	NM_010951
	NP_000264
	NP_035081
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 143, also known as Ocular albinism type 1 (OA1) in humans, is a conserved integral membrane protein with seven transmembrane domains and similarities with G protein-coupled receptors (GPCRs) that is expressed in the eye and epidermal melanocytes.^[4]^[5]^[6] This protein encoded by the GPR143 gene,^[7]^[8] whose variants can lead to Ocular albinism type 1.^[8]