GPR158
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Probable G-protein coupled receptor 158 (GPR158), also known as the metabotropic glycine receptor (mGlyR),[5] is a protein that in humans is encoded by the GPR158 gene.[6]
| GPR158 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | GPR158, G protein-coupled receptor 158 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 614573; MGI: 2441697; HomoloGene: 19381; GeneCards: GPR158; OMA:GPR158 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
This protein is an orphan class C GPCR. It is highly expressed in the brain, where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing it to the plasma membrane.[7]
It is expressed at lower levels in other organs and shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.[8]
Clinical significance
Role in mood regulation
GPR158 in the medial prefrontal cortex (mPFC) has been shown to regulate stress-induced depression in a mouse model of depression and has been found to be upregulated in post-mortem tissue samples from humans with major depressive disorder (MDD).[9]
Role in prostate cancer
The GPR158 gene is an androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines, and it is linked to neuroendocrine differentiation.[10]
