GPR25

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Probable G-protein coupled receptor 25 is a protein that in humans is encoded by the GPR25 gene.[5][6]

AliasesGPR25, G protein-coupled receptor 25
End200,874,178 bp[1]
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GPR25
Identifiers
AliasesGPR25, G protein-coupled receptor 25
External IDsOMIM: 602174; MGI: 2686146; HomoloGene: 3872; GeneCards: GPR25; OMA:GPR25 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005298

NM_001101516

RefSeq (protein)

NP_005289

NP_001094986

Location (UCSC)Chr 1: 200.87 – 200.87 MbChr 1: 136.19 – 136.19 Mb
PubMed search[3][4]
Wikidata
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Structure

It is a member of the G protein-coupled receptor (GPCR) family and it's well conserved in vertebrate evolution containing a canonical DRYLAVV motif in the third transmembrane sequence. It has a conserved negatively charged N-terminal extracellular peptide comprising a DY candidate sulfation site that is characteristic of many leukocyte chemoattractant receptors for positively charged polypeptides of the chemokine family.[7]

Tissue distribution

GPR25 expression is largely restricted to lymphocytes and natural killer (NK) cells.[7]

Function

It has been identified as the receptor for the chemokine-like protein CXCL17.[7]

References

Further reading

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