GPRC5D
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene.[5] GPRC5D is a class C orphan G protein-coupled receptor predominantly expressed in multiple myeloma cells and hard keratinized tissues, with low expression in normal human tissues, rendering it an appealing target for multiple myeloma cells.[6][7][8]
| GPRC5D | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | GPRC5D, G protein-coupled receptor, class C, group 5, member D, G protein-coupled receptor class C group 5 member D | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 607437; MGI: 1935037; HomoloGene: 10250; GeneCards: GPRC5D; OMA:GPRC5D - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Structure
Structural analysis of the complex between GPRC5D and talquetamab, a bispecific antibody for the treatment of multiple myeloma, has revealed that GPRC5D exists as a dimer. GPRC5D forms a symmetric dimer via TM4 and TM4/TM5 interactions. The study further demonstrated that only one talquetamab molecule can bind to the dimeric form of GPRC5D. Talquetamab Fab recognizes ECLs and TM3/5/7 of one GPRC5D protomer via six CDRs.[9]
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Function
The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined.[5]
