Glutathione peroxidase 6

Glutathione peroxidase 6 (GPx-6) is an enzyme that in humans is encoded by the GPX6 gene.^[5][6]

AliasesGPX6, GPX5p, GPXP3, GPx-6, GSHPx-6, dJ1186N24, dJ1186N24.1, glutathione peroxidase 6

External IDsOMIM: 607913; MGI: 1922762; HomoloGene: 130008; GeneCards: GPX6; OMA:GPX6 - orthologs

Chr.Chromosome 6 (human)^[1]

End28,528,215 bp^[1]

Quick facts GPX6, Identifiers ...

GPX6
Identifiers
Aliases	GPX6, GPX5p, GPXP3, GPx-6, GSHPx-6, dJ1186N24, dJ1186N24.1, glutathione peroxidase 6
External IDs	OMIM: 607913; MGI: 1922762; HomoloGene: 130008; GeneCards: GPX6; OMA:GPX6 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 28,503,296 bp[1] End 28,528,215 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 21,496,295 bp[2] End 21,503,794 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad olfactory zone of nasal mucosa right testis left testis islet of Langerhans lung colon wall of intestine muscle layer of sigmoid colon Top expressed in olfactory epithelium spermatid right kidney zygote outer renal medulla seminiferous tubule secondary oocyte human kidney primary oocyte urethra More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity glutathione peroxidase activity peroxidase activity Cellular component extracellular region Biological process cellular oxidant detoxification response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 257202 75512 Ensembl ENSG00000281185 ENSG00000198704 ENSMUSG00000004341 UniProt P59796 Q91WR8 RefSeq (mRNA) NM_182701 NM_145451 RefSeq (protein) NP_874360 NP_663426 Location (UCSC) Chr 6: 28.5 – 28.53 Mb Chr 13: 21.5 – 21.5 Mb PubMed search [3] [4]
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This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Expression of this gene is restricted to embryos and adult olfactory epithelium.^[5]