GRB10

The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.^[5]

Mice whose paternally inherited GRB10 gene is inactivated are more aggressive while those whose maternally inherited allele is inactivated exhibit foetal overgrowth and are significantly bigger than wild-type litter-mates.^[9]

GRB10 has been shown to interact with

• Abl gene,^[10][11]
• BCR gene,^[10]
• C-Raf,^[12][13]
• c-Kit,^[14]
• Insulin receptor,^{[11][15][16][17][18]}
• Insulin-like growth factor 1 receptor,^{[18][19][20][21]}
• MAP2K1,^[13] and
• RET proto-oncogene.^[22]