GRHPR

Glyoxylate reductase/hydroxypyruvate reductase is an enzyme that in humans is encoded by the GRHPR gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesGRHPR, GLXR, GLYD, PH2, glyoxylate reductase/hydroxypyruvate reductase, glyoxylate and hydroxypyruvate reductase

External IDsOMIM: 604296; MGI: 1923488; HomoloGene: 49088; GeneCards: GRHPR; OMA:GRHPR - orthologs

Chr.Chromosome 9 (human)^[1]

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GRHPR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GCG, 2H1S, 2Q50, 2WWR
Identifiers
Aliases	GRHPR, GLXR, GLYD, PH2, glyoxylate reductase/hydroxypyruvate reductase, glyoxylate and hydroxypyruvate reductase
External IDs	OMIM: 604296; MGI: 1923488; HomoloGene: 49088; GeneCards: GRHPR; OMA:GRHPR - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.2 Start 37,422,666 bp[1] End 37,436,990 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 44,981,395 bp[2] End 44,990,734 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right adrenal gland left adrenal gland right adrenal cortex left adrenal cortex tendon of biceps brachii human kidney muscle of thigh apex of heart C1 segment Top expressed in left lobe of liver right kidney proximal tubule Ileal epithelium human kidney adrenal gland yolk sac cumulus cell epithelium of stomach brown adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycerate dehydrogenase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor protein homodimerization activity NAD binding carboxylic acid binding NADP binding NADPH binding oxidoreductase activity hydroxypyruvate reductase activity glyoxylate reductase (NADP+) activity Cellular component cytoplasm peroxisomal matrix extracellular exosome cytosol Biological process dicarboxylic acid metabolic process excretion protein complex oligomerization metabolism cellular nitrogen compound metabolic process glyoxylate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9380 76238 Ensembl ENSG00000137106 ENSMUSG00000035637 UniProt Q9UBQ7 Q91Z53 RefSeq (mRNA) NM_012203 NM_080289 NM_001312880 RefSeq (protein) NP_036335 NP_001299809 NP_525028 Location (UCSC) Chr 9: 37.42 – 37.44 Mb Chr 4: 44.98 – 44.99 Mb PubMed search [3] [4]
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This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.^[7] GRHPR mutation analysis needs to pay attention to primer design, because allele dropout can cause false-positive result.^[8]