GRIK3

Glutamate receptor, ionotropic kainate 3 is a protein that in humans is encoded by the GRIK3 gene.^[5][6]

AliasesGRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a, glutamate ionotropic receptor kainate type subunit 3

External IDsOMIM: 138243; MGI: 95816; HomoloGene: 73901; GeneCards: GRIK3; OMA:GRIK3 - orthologs

Chr.Chromosome 1 (human)^[1]

End37,034,515 bp^[1]

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GRIK3
Identifiers
Aliases	GRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a, glutamate ionotropic receptor kainate type subunit 3
External IDs	OMIM: 138243; MGI: 95816; HomoloGene: 73901; GeneCards: GRIK3; OMA:GRIK3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 36,795,527 bp[1] End 37,034,515 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 58.91 cM Start 125,384,493 bp[2] End 125,607,966 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve spinal ganglia trigeminal ganglion prefrontal cortex primary visual cortex endothelial cell hypothalamus cingulate gyrus anterior cingulate cortex right frontal lobe Top expressed in median eminence arcuate nucleus lateral septal nucleus Rostral migratory stream lateral hypothalamus ventromedial nucleus mammillary body anterior amygdaloid area paraventricular nucleus of hypothalamus primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kainate selective glutamate receptor activity adenylate cyclase inhibiting G protein-coupled glutamate receptor activity ion channel activity extracellularly glutamate-gated ion channel activity ligand-gated ion channel activity ionotropic glutamate receptor activity G protein-coupled receptor binding glutamate receptor activity signaling receptor activity ligand-gated ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane cell junction dendrite cytoplasm perikaryon dendrite terminal bouton axon kainate selective glutamate receptor complex presynaptic membrane glutamatergic synapse Biological process G protein-coupled glutamate receptor signaling pathway glutamate receptor signaling pathway ion transport ion transmembrane transport negative regulation of synaptic transmission, glutamatergic ionotropic glutamate receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway regulation of membrane potential excitatory postsynaptic potential synaptic transmission, glutamatergic modulation of chemical synaptic transmission regulation of presynaptic membrane potential regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2899 14807 Ensembl ENSG00000163873 ENSMUSG00000001985 UniProt Q13003 B1AS29 RefSeq (mRNA) NM_000831 NM_001081097 RefSeq (protein) NP_000822 NP_001074566 Location (UCSC) Chr 1: 36.8 – 37.03 Mb Chr 4: 125.38 – 125.61 Mb PubMed search [3] [4]
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This gene encodes a protein that belongs to the ligand-gated ionic channel family. It can coassemble with either GRIK4 or GRIK5 to form heteromeric receptors and acts as an excitatory neurotransmitter at many synapses in the central nervous system. RNA editing in the mRNA has been reported.^[6]