GRIK5

GRIK5
Identifiers
Aliases	GRIK5, EAA2, GRIK2, GluK5, KA2, glutamate ionotropic receptor kainate type subunit 5
External IDs	OMIM: 600283; MGI: 95818; HomoloGene: 1578; GeneCards: GRIK5; OMA:GRIK5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	42,070,206 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	25,072,346 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; lateral nuclear group of thalamus; ; ventral tegmental area; ; subthalamic nucleus; ; vena cava; ; superior vestibular nucleus; ; inferior ganglion of vagus nerve; ; pons; ; external globus pallidus; ; pars compacta;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; entorhinal cortex; ; perirhinal cortex; ; CA3 field; ; neural layer of retina; ; olfactory tubercle; ; ventricular zone; ; primary motor cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	glutamate receptor activity; PDZ domain binding; kainate selective glutamate receptor activity; SH3 domain binding; ion channel activity; ionotropic glutamate receptor activity; identical protein binding; extracellularly glutamate-gated ion channel activity; ligand-gated ion channel activity; signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; perikaryon; postsynaptic membrane; kainate selective glutamate receptor complex; membrane; postsynaptic density; synapse; cell junction; terminal bouton; axon; dendrite; soma; endoplasmic reticulum; neuron projection; ionotropic glutamate receptor complex; presynaptic membrane; nucleus; plasma membrane; hippocampal mossy fiber to CA3 synapse; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; integral component of postsynaptic density membrane;
Biological process	synaptic transmission, glutamatergic; regulation of membrane potential; ion transport; receptor clustering; protein retention in ER lumen; regulation of synaptic vesicle fusion to presynaptic active zone membrane; ion transmembrane transport; positive regulation of neuron apoptotic process; establishment of localization in cell; ionotropic glutamate receptor signaling pathway; excitatory postsynaptic potential; cellular response to glucose stimulus; chemical synaptic transmission; modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	2901
	14809
	ENSG00000105737
	ENSMUSG00000003378
	Q16478
	Q61626
	NM_001301030; NM_002088
	NM_008168; NM_001360067
	NP_001287959; NP_002079
	NP_032194; NP_001346996; NP_001389776; NP_001389777; NP_001389778
	Wikidata
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