GSTO1

Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesGSTO1, GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, glutathione S-transferase omega 1

External IDsOMIM: 605482; MGI: 1342273; HomoloGene: 37971; GeneCards: GSTO1; OMA:GSTO1 - orthologs

EC number1.20.4.2

Quick facts Available structures, PDB ...

GSTO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EEM, 3LFL, 3VLN, 4IS0
Identifiers
Aliases	GSTO1, GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, glutathione S-transferase omega 1
External IDs	OMIM: 605482; MGI: 1342273; HomoloGene: 37971; GeneCards: GSTO1; OMA:GSTO1 - orthologs
EC number	1.20.4.2
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.1 Start 104,235,356 bp[1] End 104,267,459 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D1 Start 47,843,409 bp[2] End 47,853,229 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte right lobe of liver right lung middle temporal gyrus kidney tubule right auricle of heart left ventricle apex of heart right ventricle gingival epithelium Top expressed in conjunctival fornix corneal stroma ciliary body gastric mucosa mucous cell of stomach epithelium of stomach superior surface of tongue pyloric antrum duodenum esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity glutathione dehydrogenase (ascorbate) activity protein binding methylarsonate reductase activity oxidoreductase activity glutathione transferase activity Cellular component cytoplasm cytosol extracellular exosome Biological process xenobiotic catabolic process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity methylation cellular response to arsenic-containing substance positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion metabolism regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum glutathione derivative biosynthetic process L-ascorbic acid metabolic process cellular oxidant detoxification glutathione metabolic process toxin catabolic process interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9446 14873 Ensembl ENSG00000148834 ENSMUSG00000025068 UniProt P78417 Q5TA02 O09131 RefSeq (mRNA) NM_004832 NM_001191002 NM_001191003 NM_010362 RefSeq (protein) NP_001177931 NP_001177932 NP_004823 NP_034492 Location (UCSC) Chr 10: 104.24 – 104.27 Mb Chr 19: 47.84 – 47.85 Mb PubMed search [3] [4]
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This gene encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis.^[7] This protein has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism.^[8]