GSTT1

Glutathione S-transferase theta-1 is an enzyme that in humans is encoded by the GSTT1 gene.^[2]

PDBHuman UniProt search: PDBe RCSB

AliasesGSTT1, glutathione S-transferase theta 1

External IDsOMIM: 600436; GeneCards: GSTT1; OMA:GSTT1 - orthologs

Chr.Chromosome 22 (human)

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GSTT1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2C3N, 2C3Q, 2C3T
Identifiers
Aliases	GSTT1, glutathione S-transferase theta 1
External IDs	OMIM: 600436; GeneCards: GSTT1; OMA:GSTT1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.23 Start 24,376,133 bp End 24,384,680 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava thoracic diaphragm adrenal gland external globus pallidus jejunal mucosa right ventricle coronary artery Skeletal muscle tissue of rectus abdominis lateral nuclear group of thalamus cingulate gyrus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity glutathione peroxidase activity glutathione transferase activity protein binding Cellular component cytoplasm cytosol extracellular exosome Biological process glutathione derivative biosynthetic process glutathione metabolic process cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2952 n/a Ensembl ENSG00000277656 n/a UniProt P30711 n/a RefSeq (mRNA) NM_000853 NM_001293807 NM_001293808 NM_001293809 NM_001293810 NM_001293811 NM_001293812 NM_001293813 NM_001293814 n/a RefSeq (protein) NP_000844 NP_001280736 NP_001280737 NP_001280738 NP_001280739 NP_001280740 NP_001280741 NP_001280742 NP_001280743 n/a Location (UCSC) Chr 22: 24.38 – 24.38 Mb n/a PubMed search [1] n/a
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Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.^[3]